Characterization of human epigenomes.

Perspectives of International Human Epigenome Consortium

As the International Human Epigenome Consortium (IHEC) launched officially at the 2010 Washington meeting, a giant step toward the conquest of unexplored regions of the human genome has begun. IHEC aims at the production of 1,000 reference epigenomes to the international scientific community for next 7-10 years. Seven member institutions, including South Korea, Korea National Institute of Healt...

Mining Novel Candidate Imprinted Genes Using Genome-Wide Methylation Screening and Literature Review

Large-scale transcriptome and methylome data analyses obtained by high-throughput technologies have been enabling the identification of novel imprinted genes. We investigated genome-wide DNA methylation patterns in multiple human tissues, using a high-resolution microarray to uncover hemimethylated CpGs located in promoters overlapping CpG islands, aiming to identify novel candidate imprinted g...

A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.

Recent whole-genome sequencing of thousands of human cancers has uncovered an unexpectedly large number of mutations in genes, which control the epigenome. Many of these recurrent mutations are in epigenetic writers (e.g., EZH2, DNMT3a), readers (BRD4-NUT fusions), erasers (UTX mutations), and chromatin remodeling enzymes (BAF subunits of SWI/SNF). They occur at high frequencies and may therefo...

Characterization of the Properties of Mouse-Adapted Human Measles Virus (34333)

The Isolation and Characterization a Human Diploid Cell Strain and Its Use in Production of Measles Vaccine